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Experimental design. After the creation of status epilepticus model and applying ketamine, propofol, and drug combinations, <t>video‐EEG</t> <t>recording</t> was performed.
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Experimental design. After the creation of status epilepticus model and applying ketamine, propofol, and drug combinations, video‐EEG recording was performed.

Journal: Journal of Neuroscience Research

Article Title: Efficacy of Low‐Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats

doi: 10.1002/jnr.25393

Figure Lengend Snippet: Experimental design. After the creation of status epilepticus model and applying ketamine, propofol, and drug combinations, video‐EEG recording was performed.

Article Snippet: Data on spike frequency (Hz) and amplitude (mV) from EEG recordings were converted to numerical values using EEG recording software (LabChart v8.1, AD Instruments, Castle Hill, Australia).

Techniques:

Spike frequencies related to status epilepticus during the 140‐min EEG recording period after the application of ketamine, propofol, and antiepileptic drug combinations. Spike frequencies before the application of treatments are also shown at the top. All animals in the status epilepticus group died shortly after seizure induction and, therefore, were not included in the figure. The graphs show the median (min‐max and Q1–Q3) spike frequency values for 1 min of activity, obtained at 20‐min intervals ( p values are shown compared to 20 mg/kg propofol group, statistics determined with Kruskal–Wallis (KW) followed by Mann–Whitney U test).

Journal: Journal of Neuroscience Research

Article Title: Efficacy of Low‐Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats

doi: 10.1002/jnr.25393

Figure Lengend Snippet: Spike frequencies related to status epilepticus during the 140‐min EEG recording period after the application of ketamine, propofol, and antiepileptic drug combinations. Spike frequencies before the application of treatments are also shown at the top. All animals in the status epilepticus group died shortly after seizure induction and, therefore, were not included in the figure. The graphs show the median (min‐max and Q1–Q3) spike frequency values for 1 min of activity, obtained at 20‐min intervals ( p values are shown compared to 20 mg/kg propofol group, statistics determined with Kruskal–Wallis (KW) followed by Mann–Whitney U test).

Article Snippet: Data on spike frequency (Hz) and amplitude (mV) from EEG recordings were converted to numerical values using EEG recording software (LabChart v8.1, AD Instruments, Castle Hill, Australia).

Techniques: Activity Assay, MANN-WHITNEY

Spike amplitudes related to status epilepticus during the 140‐min EEG recording period after the application of ketamine, propofol, and antiepileptic drug combinations. Spike amplitudes before the application of treatments are also shown at the top. All animals in the status epilepticus group died shortly after seizure induction and, therefore, were not included in the figure. The graphs show the median (min‐max and Q1–Q3) spike amplitude values for 1 min of activity, obtained at 20‐min intervals ( p values are shown compared to 20 mg/kg propofol group, statistics determined with Kruskal–Wallis (KW) followed by Mann–Whitney U test).

Journal: Journal of Neuroscience Research

Article Title: Efficacy of Low‐Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats

doi: 10.1002/jnr.25393

Figure Lengend Snippet: Spike amplitudes related to status epilepticus during the 140‐min EEG recording period after the application of ketamine, propofol, and antiepileptic drug combinations. Spike amplitudes before the application of treatments are also shown at the top. All animals in the status epilepticus group died shortly after seizure induction and, therefore, were not included in the figure. The graphs show the median (min‐max and Q1–Q3) spike amplitude values for 1 min of activity, obtained at 20‐min intervals ( p values are shown compared to 20 mg/kg propofol group, statistics determined with Kruskal–Wallis (KW) followed by Mann–Whitney U test).

Article Snippet: Data on spike frequency (Hz) and amplitude (mV) from EEG recordings were converted to numerical values using EEG recording software (LabChart v8.1, AD Instruments, Castle Hill, Australia).

Techniques: Activity Assay, MANN-WHITNEY

Effect of ketamine, propofol, and antiepileptic drug combinations on seizure parameters. Seizure onset latency shows the median (min‐max and Q1–Q3) values for the time until the onset of seizure activity after 320 mg/kg pilocarpine injection. The latency of drug efficacy represents the time until the onset of the first statistically significant decrease in spike frequency, according to the 20 mg/kg propofol group. Mortality latency shows the median (min‐max and Q1–Q3) values of the animal death time from pilocarpine injection to the end of the EEG recording. Mortality rate shows the percentage of animal deaths due to status epilepticus in the experimental groups ( p values are shown compared to the status epilepticus group, statistics determined with Kruskal–Wallis (KW) followed by Mann–Whitney U test).

Journal: Journal of Neuroscience Research

Article Title: Efficacy of Low‐Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats

doi: 10.1002/jnr.25393

Figure Lengend Snippet: Effect of ketamine, propofol, and antiepileptic drug combinations on seizure parameters. Seizure onset latency shows the median (min‐max and Q1–Q3) values for the time until the onset of seizure activity after 320 mg/kg pilocarpine injection. The latency of drug efficacy represents the time until the onset of the first statistically significant decrease in spike frequency, according to the 20 mg/kg propofol group. Mortality latency shows the median (min‐max and Q1–Q3) values of the animal death time from pilocarpine injection to the end of the EEG recording. Mortality rate shows the percentage of animal deaths due to status epilepticus in the experimental groups ( p values are shown compared to the status epilepticus group, statistics determined with Kruskal–Wallis (KW) followed by Mann–Whitney U test).

Article Snippet: Data on spike frequency (Hz) and amplitude (mV) from EEG recordings were converted to numerical values using EEG recording software (LabChart v8.1, AD Instruments, Castle Hill, Australia).

Techniques: Activity Assay, Injection, MANN-WHITNEY